Why does Avelox help relieve bronchitis?
Which pathogen is causing a bacterial flare-up of chronic bronchitis can be very difficult for a doctor to determine. One solution is to treat patients with an antibiotic that is active against many types of bacteria (a broad-spectrum antibiotic). Avelox is a broad-spectrum antibiotic that is highly active against many kinds of bacteria, including those that are most likely to cause flare-ups: Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis.

Avelox is also active against less common, but potentially dangerous, respiratory pathogens (such as Klebsiella pneumoniae) and a group of germs called atypical pathogens (such as those of the species Mycoplasma).

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Drug-resistant bacteria are becoming increasingly common. Because Avelox works differently from most other antibiotics, it often continues to be effective against pathogens that are resistant to other drugs.

To kill bacteria, an antibiotic must reach the place where they are causing trouble-the infected tissues. Avelox does this. Being able to penetrate tissues throughout the respiratory tract may allow the drug to kill bacteria more effectively.

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What studies have been done to prove that AVELOX works?
Research studies involving thousands of patients have shown that Avelox is an effective treatment for bacterial flare-ups of chronic bronchitis.

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In two studies examining time to recovery in acute bacterial exacerbations of chronic bronchitis, patients treated with Avelox reported significantly faster recovery rates than patients receiving standard antibiotic therapy such as amoxicillin-clavulanate, clarithromycin, or cefuroxime.  Furthermore, in a study focused specifically on patients with a smoking history and moderate to severe disease, patients treated with Avelox experienced a significantly longer remission of disease (longer time to the next flare-up) than patients treated with amoxicillin, clarithromycin, or cefuroxime.

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What are the side effects of Avelox?
Most people who take Avelox do not have major side effects. The most common side effects are usually mild. For more information, see the Avelox (moxifloxacin hydrochloride) Patient Information.

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Is there anything you should worry about when you are taking Avelox?
Some  rare, serious side effects have been reported in patients taking any of the quinolone antibiotics, including Avelox. If you experience heart palpitations, fainting spells, convulsions, or pain in a tendon, contact your health care provider immediately.

Because some patients feel dizzy when they take Avelox, you should not drive a motor vehicle (including motorcycles) or operate machinery until you are sure that you can take Avelox without having a dizzy spell.

Do not take certain other medications while you are taking Avelox. These include medicines used to treat abnormal heart rhythms (quinidine, procainamide, amiodarone, and sotalol) and medicines that change electrocardiogram (ECG) patterns (cisapride, erythromycin, some antidepressants, and some antipsychotic drugs). Many antacids and multivitamins interfere with how well the body accepts Avelox and may prevent it from working properly. Always take Avelox at least 4 hours before or 8 hours after taking any of these products. Consult your health care provider for more information about this.

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How can I get Avelox?
Avelox is available only by prescription from a health care provider.

Avelox is generally given once a day for 5 days for the treatment of Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB).

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Patient Prescribing Information
This section contains important information about Avelox (moxifloxacin hydrochloride), and should be read completely before you begin treatment. This section does not take the place of discussions with your doctor or health care professional about your medical condition or your treatment. This section does not list all benefits and risks of Avelox. The medicine described here can be prescribed only by a licensed health care professional. If you have any questions about Avelox talk with your health care professional. Only your health care professional can determine if Avelox is right for you.

What is Avelox?
Avelox is an antibiotic used to treat lung, sinus, or skin infections caused by certain germs called bacteria. Avelox kills many of the types of bacteria that can infect the lungs and sinuses and has been shown in a large number of clinical trials to be safe and effective for the treatment of bacterial infections.

Sometimes viruses rather than bacteria may infect the lungs and sinuses (for example the common cold). Avelox, like all other antibiotics, does not kill viruses.

You should contact your doctor if you think your condition is not improving while taking Avelox.

Avelox Tablets are red and contain 400 mg of active drug.

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How and when should I take Avelox?
Avelox should be taken once a day for 5-14 days depending on your prescription. It should be swallowed and may be taken with or without food. Try to take the tablet at the same time each day.

You may begin to feel better quickly; however, in order to make sure that all bacteria are killed, you should complete the full course of medication. Do not take more than the prescribed dose of Avelox even if you missed a dose by mistake. You should not take a double dose.

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Who should not take Avelox?
You should not take Avelox if you have ever had a severe allergic reaction to any of the group of antibiotics known as "quinolones" such as ciprofloxacin or levofloxacin. If you develop hives, difficulty breathing, or other symptoms of a severe allergic reaction, seek emergency treatment right away. If you develop a skin rash, you should stop taking Avelox and call your health care professional.

You should avoid Avelox if you have a rare condition known as congenital prolongation of the QT interval. If you or any of your family members have this condition you should inform your health care professional. You should avoid Avelox if you are being treated for heart rhythm disturbances with certain medicines such as quinidine, procainamide, amiodarone or sotalol. Inform your health care professional if you are taking a heart rhythm drug.

You should also avoid Avelox if the amount of potassium in your blood is low. Low potassium can sometimes be caused by medicines called diuretics such as furosemide and hydrochlorothiazide. If you are taking a diuretic medicine you should speak with your health care professional.

If you are pregnant or planning to become pregnant while taking Avelox, talk to your doctor before taking this medication. Avelox is not recommended for use during pregnancy or nursing, as the effects on the unborn child or nursing infant are unknown.

Avelox is not recommended for children.

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What are the possible side effects of Avelox?
Avelox   is generally well tolerated. The most common side effects caused by Avelox, which are usually mild, include dizziness, nausea, and diarrhea. If diarrhea persists call your health care provider. You should be careful about driving or operating machinery until you are sure Avelox is not causing dizziness. If you notice any side effects not mentioned in this section or you have any concerns about the side effects you are experiencing, please inform your health care professional.

In some people, Avelox, as with some other antibiotics, may produce a small effect on the heart that is seen on an electrocardiogram test. Although this has not caused any serious problems in more than 7,900 patients who have already taken the medication in clinical studies, in theory it could result in extremely rare cases of abnormal heartbeat which may be dangerous. Contact your health care professional if you develop heart palpitations (fast beating), or have fainting spells.

Convulsions have been reported in patients receiving quinolone antibiotics. Be sure to let your physician know if you have a history of convulsions. Quinolones, including Avelox, have been rarely associated with other central nervous system events including confusion, tremors, hallucinations, and depression.

Quinolones, including Avelox, have been rarely associated with inflammation of tendons. If you experience pain, swelling or rupture of a tendon, you should stop taking Avelox and call your health care professional.

What about other medicines I am taking?
Tell your doctor about all other prescription and non-prescription medicines or supplements you are taking. You should avoid taking Avelox with certain medicines used to treat an abnormal heartbeat. These include quinidine, procainamide, amiodarone, and sotalol.

Some medicines also produce an effect on the electrocardiogram test, including cisapride, erythromycin, some antidepressants and some antipsychotic drugs. These may increase the risk of heartbeat problems when taken with Avelox.

Many antacids and multivitamins may interfere with the absorption of Avelox and may prevent it from working properly. You should take Avelox either 4 hours before or 8 hours after taking these products.

Remember
Take your dose of Avelox once a day.

Complete the course of medication even if you are feeling better.

Keep this medication out of the reach of children.

This information does not take the place of discussions with your doctor or health care professional about your medical condition or your treatment.

For more complete information about Avelox request full prescribing information from your health care professional or pharmacist.

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